https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology offers a range of options to lead to biology. Below I'll current illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some examples from our lab:
Our team scientific studies bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin framework, and spatial Management.
[Laughs] ‘It absolutely was unquestionably an incredible possibility! At enough time, I used to be effectively mindful that it could go Improper and that I could turn out to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Considering the fact that 2000, Dekker has shifted the principle aim of his perform toward biophysics where by he scientific studies the Houses of one biomolecules and cells utilizing the tools of nanotechnology. This variation of industry was driven by his fascination for your impressive performing of Organic molecular structures, in addition to with the very long-time period perspective that a lot of exciting discoveries is often envisioned in this field.[5] Present traces of analysis in his biophysics group are while in the regions of:[six]
2010, produced a whole new way (‘wedging transfer’) to govern nanostructures; to start with report of DNA translocation through graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores
SMC complexes can pass Actual physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
Many related developments followed, exactly where our group set up different transistor variants which include single-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into little evidence-of-theory electronic circuits.
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
‘Of course, I comprehend men and women were stunned at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to admit that it experienced turn into a bit bored, I didn’t understand much any more. The sector went much more into the appliance facet, how you could integrate nanotubes into Digital circuits.
But carbon nanotubes have remained a study topic of substantial interest to numerous. Indeed, the outlook on using carbon nanotubes to construct sensible gadgets, in locations such as radio-frequency electronics, electronic electronics and versatile electronics, remains bright.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
Later on we spoke yet again briefly because Dekker felt that our discussion of his faith swiftly grew to become purely philosophical, Whilst it also concretely assists him in his perform.
Allow’s very first seem back again at this time when you decided to change your focus from superconductivity and nanotubes to biology at the end of the nineteen nineties.
2004, https://www.ceesdekker.net discovery of new physics in translocation of DNA by nanopores; 1st experimental study of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization of your mechanical Homes of double-stranded RNA; and first solitary-molecule study of DNA translocation by a restriction-modification enzyme.